Spectral pitch distance and microtonal melodies

We present an experiment designed to test the effectiveness of spectral pitch distance at modeling the degree of “affinity” or “fit” of pairs of successively played tones or chords (spectral pitch distance is the cosine distance between salience-weighted, Gaussian-smoothed, pitch domain embeddings of spectral pitches—typically the first eight to ten partials of a tone). The results of a previously conducted experiment, which collected ratings of the perceived similarity and fit of root-position major and minor triads, suggest the model works well for pairs of triads in standard 12-tone equal temperament tunings. The new experiment has been designed to test the effectiveness of spectral pitch distance at modeling the affinity of tones in microtonal melodies where the partials of the tones can be variably tempered between being perfectly harmonic and perfectly matched to the underlying microtonal tuning. The use of microtonal tunings helps to disambiguate innate perceptual (psychoacoustical) responses from learned (cultural) responses. Participants are presented with a software synthesizer containing two unlabeled controls: one adjusts the precise tuning of the tones; the other adjusts the extent to which the spectrum is tempered to match the tuning (as set by the first control). A selection of microtonal melodies are played in different tunings, and the participants adjust one, or both, controls until they find a “sweet spot” at which the music sounds most “in-tune” and the notes best “fit” together. The results of these experiments will be presented and discussed

Metrics for pitch collections

Models of the perceived distance between pairs of pitch collections are a core component of broader models of the perception of tonality as a whole. Numerous different distance measures have been proposed, including voice-leading, psychoacoustic, and pitch and interval class distances; but, so far, there has been no attempt to bind these different measures into a single mathematical framework, nor to incorporate the uncertain or probabilistic nature of pitch perception (whereby tones with similar frequencies may, or may not, be heard as having the same pitch). To achieve these aims, we embed pitch collections in novel multi-way expectation arrays, and show how metrics between such arrays can model the perceived dissimilarity of the pitch collections they embed. By modeling the uncertainties of human pitch perception, expectation arrays indicate the expected number of tones, ordered pairs of tones, ordered triples of tones and so forth, that are heard as having any given pitch, dyad of pitches, triad of pitches, and so forth. The pitches can be either absolute or relative (in which case the arrays are invariant with respect to transposition). We provide a number of examples that show how the metrics accord well with musical intuition, and suggest some ways in which this work may be developed

Hex Player—a virtual musical controller

In this paper, we describe a playable musical interface for tablets and multi-touch tables. The interface is a generalized keyboard, inspired by the Thummer, and consists of an array of virtual buttons. On a generalized keyboard, any given interval always has the same shape (and therefore fingering); furthermore, the fingering is consistent over a broad range of tunings. Compared to a physical generalized keyboard, a virtual version has some advantages—notably, that the spatial location of the buttons can be transformed by shears and rotations, and their colouring can be changed to reflect their musical function in different scales. We exploit these flexibilities to facilitate the playing not just of conventional Western scales but also a wide variety of microtonal generalized diatonic scales known as moment of symmetry, or well-formed, scales. A user can choose such a scale, and the buttons are automatically arranged so their spatial height corresponds to their pitch, and buttons an octave apart are always vertically above each other. Furthermore, the most numerous scale steps run along rows, while buttons within the scale are light-coloured, and those outside are dark or removed. These features can aid beginners; for example, the chosen scale might be the diatonic, in which case the piano’s familiar white and black colouring of the seven diatonic and five chromatic notes is used, but only one scale fingering need ever be learned (unlike a piano where every key needs a different fingering). Alternatively, it can assist advanced composers and musicians seeking to explore the universe of unfamiliar microtonal scales

Play that funky music: Making 3D acoustic measurements of instruments under performance conditions.

This research involves the design and implementation of a high spatial resolution acoustic radiation measurement system for the purpose of collecting data about the acoustic radiation in 3 dimensions from musical instruments while they are being played by musicians. It is also possible for the system to be used to capture 3 dimensional data about other sound sources. Each musician may, when they perform upon their instrument, attempt to play consistently with the same dynamics and tone, the same timing and feeling, but will ultimately fail. This is not a failing in the musician themselves, but rather a function of the fact that musicians are, like all people, biological beings, and therefore cannot perform exactly the same movement with the consistency required for scientific data gathering when the purpose of the movement is to actuate another object (the instrument in this case). The problem has been attempted to be solved by taking the musician out of the measurement process, and by mechanically actuating the instrument in order to make repeatable and consistent measurements, but this rather defeats the purpose, as the instrument will not play (in performance) without the musician present. The very presence of the musician will change the acoustic behaviour of the musical instrument as the musician will absorb some of the acoustic energy radiated from the instrument, especially at high frequencies, and to a lesser extent, the mid-range and lower frequencies within the audible spectrum. (This is related to the physical wavelength of the sound pressure wave – where it is smaller than the dimensions of the human body of the musician it will tend to be absorbed, but when longer it will tend to diffract around the body and will not be absorbed much, if at all). So, it has been proposed to make the acoustic radiation measurement system compatible with an instrument actually being played. This will involve a grid of sensors which surround the musician, taking measurements of data at spatially averaged points, but with higher spatial resolution than in any of the previously surveyed literature. This will allow the interpolation of that data in order to predict the frequency-amplitude response and the phase of those frequency components in any given direction around the instrument (or other sound source) which has been measured. In order to make high resolution measurements of the acoustic behaviour of musical instruments under performance conditions, a measurement system has been designed which consists of a number of interconnected parts. These include the sensors arranged in array on a 3 dimensional grid, signal conditioning circuits to bias the sensors, a set of analogue to digital convertors to send the signals to the data capture devices, and an array of hard disk data recorders to capture the data being generated by the sensors. When the data is captured, it can be then organised, processed, analysed and displayed in various ways

Identification of a non-mammalian leptin-like gene:characterization and expression in the tiger salamander (Ambystoma tigrinum)

Leptin is well established as a multifunctional cytokine in mammals. However, little is known about the evolution of the leptin gene in other vertebrates. A recently published set of ESTs from the tiger salamander (Ambystoma tigrinum) contains a sequence sharing 56% nucleotide sequence identity with the human leptin cDNA. To confirm that the EST is naturally expressed in the salamander, a 409 bp cDNA was amplified by RT-PCR of salamander testis and stomach mRNAs. The coding sequence of the cDNA is predicted to encode 169 amino acids, and the mature peptide to consist of 146 residues, as in mammals. Although the overall amino acid identity with mammalian leptins is only 29%, the salamander and mammalian peptides share common structural features. An intron was identified between coding exons providing evidence that the sequence is present in the salamander genome. Phylogenetic analysis showed a rate of molecular divergence consistent with the accepted view of vertebrate evolution. The pattern of tissue expression of the leptin-like cDNA differed between metamorphosed adult individuals of different sizes suggesting possible developmental regulation. Expression was most prominent in the skin and testis, but was also detected in tissues in which leptin mRNA is present in mammals, including the fat body, stomach, and muscle. The characterization of a salamander leptin-like gene provides a basis for understanding how the structure and functions of leptin have altered during the evolution of tetrapod vertebrates

Public understanding of solar radiation management

We report the results of the first large-scale international survey of public perception of geoengineering and solar radiation management (SRM). Our sample of 3105 individuals in the United States, Canada and the United Kingdom was recruited by survey firms that administer internet surveys to nationally representative population samples. Measured familiarity was higher than expected, with 8% and 45% of the population correctly defining the terms geoengineering and climate engineering respectively. There was strong support for allowing the study of SRM. Support decreased and uncertainty rose as subjects were asked about their support for using SRM immediately, or to stop a climate emergency. Support for SRM is associated with optimism about scientific research, a valuing of SRM's benefits and a stronger belief that SRM is natural, while opposition is associated with an attitude that nature should not be manipulated in this way. The potential risks of SRM are important drivers of public perception with the most salient being damage to the ozone layer and unknown risks. SRM is a new technology and public opinions are just forming; thus all reported results are sensitive to changes in framing, future information on risks and benefits, and changes to context.Physic

Improved synchronous production of Plasmodium falciparum gametocytes in vitro.

The sexual stages of the Plasmodium falciparum life cycle are attractive targets for vaccines and transmission blocking drugs. Difficulties in culturing and obtaining large amounts of sexual stage P. falciparum parasites, particularly early stages, have often limited research progress in this area. We present a new protocol which simplifies the process of stimulating gametocytogenesis leading to improved synchronous gametocyte production. This new method can be adapted to enrich for early stage gametocytes (I and II) with a higher degree of purity than has previously been achieved, using MACS magnetic affinity columns. The protocol described lends itself to large scale culturing and harvesting of synchronous parasites suitable for biochemical assays, northern blots, flow cytometry, microarrays and proteomic analysis

Effectiveness and equity impacts of town-wide cycling initiatives in England: a longitudinal, controlled natural experimental study.

Cycling confers health and environmental benefits, but few robust studies have evaluated large-scale programmes to promote cycling. In England, recent years have seen substantial, town-wide cycling initiatives in six Cycling Demonstration Towns (funded 2005-2011) and 12 Cycling Cities and Towns (funded 2008-2011). The initiatives involved mixtures of capital investment (e.g. cycle lanes) and revenue investment (e.g. cycle training), tailored to each town. This controlled before-after natural experimental study used English census data to examine impacts on the prevalence of travelling to work by bicycle and other modes, comparing changes in the intervention towns with changes in three comparison groups (matched towns, unfunded towns and a national comparison group). We also compared effects between more and less deprived areas, and used random-effects meta-analysis to compare intervention effects between towns. Among 1.3 million commuters in 18 intervention towns, we found that the prevalence of cycling to work rose from 5.8% in 2001 to 6.8% in 2011. This represented a significant increase relative to all three comparison groups (e.g. +0.69 (95% CI 0.60,0.77) percentage points for intervention vs. matched towns). Walking to work also increased significantly compared with comparison towns, while driving to work decreased and public transport use was unchanged. These effects were observed across all fifths of area deprivation, with larger relative changes in deprived areas. There was substantial variation in effect sizes between towns, however, and the average town-level effect on cycling was non-significant (+0.29 (-0.26,0.84) percentage points for intervention vs. matched towns). We conclude that to date, cycling to work has increased (and driving to work decreased) in the intervention towns, in a relatively equitable manner. The variation in effects between towns indicates uncertainty regarding the likely impact of comparable investment in future towns. Nevertheless these results support the case for implementing and evaluating further town-wide cycling initiatives